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“Even so, the move is almost certain to face immediate legal action challenging the administration’s authority to keep families detained at length….. The White House may run into legal difficulties if the executive order requires families to be held intact together indefinitely since a federal consent decree known as the Flores settlement says children must be released after 20 days.”

CNN also added, “Both first lady Melania Trump and Nielsen reportedly had roles in the changing course . The first lady has been working for several days behind the scenes, encouraging the President to keep families together, a White House official told CNN. She has had several private conversations with her husband, pushing him to do all he can to keep families at the border intact, whether via a legislative route, or acting alone to stop the process, the official said.” [emphasis added] shopping online outlet sale Jil Sander Women’s Sporty Mules Black Nero 999 cheap factory outlet free shipping eastbay SLlTZzzFoe

first lady Melania Trump and Nielsen reportedly had roles in the changing course

On Thursday, The New York Times published a summary guide to the order, which we urge our readers to consult :“ Trump’s Executive Order on Family Separation, Explained,” .

summary guide Trump’s Executive Order on Family Separation, Explained,”

Whether Congress can solve many of the problems raised by the executive order by legislation is not at all clear. Read full details in Wednesday’s report in The Washington Post , here: , and the story in Politico , “ GOP immigration bills on brink of collapse,” .

GOP immigration bills on brink of collapse,”

Also in The Washington Post , columnist Aaron Blake remarks that “The Trump administration insisted it didn’t’t have a policy of separating children from their parents at the U.S.-Mexico border. It said that it was merely following the law. And it said ‘Congress alone can fix’ the mess. It just admitted that all that was nonsense — and that it badly overplayed its hand. Homeland Security Secretary Kirstjen Nielsen, who on Sunday and Monday insisted that this wasn’t’t an actual policy and that the administration’s hands are tied, will now have to untie them as the White House will reverse the supposedly nonexistent policy….Virtually everything it said about the policy is tossed aside with this executive action.”[emphasis added]

Observational registries are another crucial way of elucidating real-life outcomes of newer drugs. Relevant studies in the management of patients with AF and the prevention and treatment of venous thromboembolism (VTE) include global registries such as GLORIA-AF (GLObal RegIstry on long-term oral Antithrombotic treatment in patients with Atrial Fibrillation), 18 GARFIELD (Global Anticoagulant Registry in the FIELD) AF, 19 and GARFIELD VTE ( identifier: NCT02155491); US registries such as ORBIT-AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation) 20 ; European registries such as PREFER in AF (PREvention oF thromboembolic events—European Registry in Atrial Fibrillation) 21 and PREFER in VTE 22 and regional registries such as Fushimi AF in Japan 23 and Dresden NOAC in Germany. 24 These and other studies will be described in further detail in later articles in this supplement.

Real-life data have an important role to play in the evaluation of short- and long-term drug safety in clinical practice; the effectiveness and safety of drugs in special populations; adherence; persistence; epidemiology and burden of disease; treatment patterns and health outcomes and cost. 25

Following the drug approval process, concerns remain regarding the safety of new drugs that are introduced into the marketplace. As mentioned, RCTs use strict inclusion and exclusion criteria to enrol a defined, homogenous patient population, which can limit the translatability of the results to clinical practice. 26 Real-life studies typically have limited exclusion criteria and involve a more heterogeneous population, including higher rates of non-compliant patients and more subjects with significant comorbidities. 26 In addition, RCTs usually last for a defined period of time, which may preclude the discovery of adverse events that result from long-term administration of a therapy. Therefore, it is important that safety signals are identified to ensure the best outcomes for the general population. Post-authorization safety studies are one example of how such real-life information may be elucidated.

Real-life studies can be used to assess the effectiveness of therapy in special populations, such as patients who have renal impairment, are overweight, or are elderly. Chronic kidney disease (CKD) constitutes a risk factor for thromboembolic events, stroke, and bleeding in patients with AF. 27 Real-life data have shown that VKA therapy is associated with a significant reduction in the risk of stroke and thromboembolism in those with CKD, but the risk of bleeding is also significantly increased. 27 According to the European Heart Rhythm Association (EHRA) Practical Guide on the use of NOACs in patients with non-valvular AF, NOACs appear to be a reasonable choice for anticoagulant therapy in patients with mild-to-moderate CKD. 28 However, careful monitoring of renal function is required in patients with CKD who are receiving NOACs, since all undergo some form of renal clearance. 29–31 There are no outcome data for NOACs in patients with AF and severe CKD, and the current European Society of Cardiology (ESC) guidelines recommend against their use in such patients. 32 Clinical experience with newer agents is limited, and more data from real-life studies in patients with CKD are warranted to optimize the potential benefits of treatment and minimize the potential harm in this high-risk and growing population.